Christoph Schmidt‐Hieber

Anti-GABAB receptor autoimmunity causes cognitive decline by presynaptic pathology

This study shows that autoantibodies against GABAB receptors cause presynaptic pathology leading to cognitive decline and memory impairment.

Task engagement differentially drives hippocampal and neocortical neural codes

The paper shows that visual cortex maintains sensory discrimination regardless of behavior, while the hippocampal dentate gyrus requires active navigation for effective discrimination.

A synaptic novelty signal to switch hippocampal attractor networks from generalization to discrimination

The paper identifies a synaptic novelty signal in hippocampal circuits that drives a switch from generalization to discrimination during memory formation.

Inhibitory control of synaptic signals preceding motor action in mouse frontal cortex

The paper investigates how inhibitory neurons shape preparatory signals in the mouse frontal cortex during motor planning, finding distinct roles for parvalbumin and somatostatin interneurons.

The hippocampus as a perceptual map: neuronal and behavioral discrimination during memory encoding

This study uses 2-photon imaging in mice to show that the dentate gyrus enhances environmental differences while CA1 reflects behavioral performance during memory encoding.