Christian Geis

Anti-GABAB receptor autoimmunity causes cognitive decline by presynaptic pathology

This study shows that autoantibodies against GABAB receptors cause presynaptic pathology leading to cognitive decline and memory impairment.

Incomplete cerebellar circuit restoration limits functional recovery following SMN therapy in severe spinal muscular atrophy

The paper identifies cerebellar pathology as a conserved yet distinct feature in severe SMA, showing divergent therapeutic outcomes with SMN-restoring therapies.

Anti-NMDAR encephalitis alters intrinsic spatiotemporal coding by enhancing neuronal coupling and clustering

This study investigates how anti-NMDAR encephalitis alters neuronal network function by enhancing coupling and clustering in hippocampal neurons during slow-wave sleep.

LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening

This study investigates how LGI1 autoantibodies enhance synaptic transmission by reducing Kv1 channel density and broadening presynaptic action potentials.

It only takes seconds for a human monoclonal autoantibody to inhibit N-methyl-D-aspartate receptors

This study shows a patient-derived monoclonal antibody rapidly inhibits N-methyl-D-aspartate receptors directly, suggesting potential therapeutic strategies using antigen-binding fragments.

Peripherally derived LGI1-reactive monoclonal antibodies cause epileptic seizures in vivo

This study shows that LGI1-reactive monoclonal antibodies cause seizures in rats, with molecular and electrophysiological evidence of epileptogenesis.

A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration

The paper shows that tactile stimulation suppresses visual activity in primary visual cortex via interneurons receiving input from somatosensory cortex in mice.

Human NMDAR autoantibodies disrupt excitatory-inhibitory balance leading to hippocampal network hypersynchrony

This study shows that NMDAR autoantibodies disrupt the excitatory-inhibitory balance in the hippocampus, leading to network hypersynchrony and symptoms resembling schizophrenia.

NMDA-receptor-Fc-fusion constructs neutralize anti- NMDA receptor antibodies

This study develops NMDA-receptor-Fc-fusion constructs that neutralize anti-NMDA receptor antibodies and inhibit their effects on neurons.

Network instability dynamics drive a transient bursting period in the developing hippocampus in vivo

The paper identifies network instability dynamics as a driver of transient bursting activity in the developing hippocampus, revealing a mechanism for input-discrimination learning before environmental exploration.

Impaired functional connectivity of the hippocampus in murine models of NMDA-receptor antibody associated pathology

This study investigates functional connectivity changes in murine models of NMDAR antibody-associated pathology using rs-fMRI, finding impaired connectivity in hippocampal regions similar to human patients.

Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission

This study shows that neuronal activity drives the translocation of LGI1 and ADAM23 to the synaptic cleft, adjusting excitatory neurotransmission based on activity history.

Encephalitis patient derived monoclonal GABAA receptor antibodies cause catatonia and epileptic seizures

The paper demonstrates that patient-derived monoclonal GABAA receptor antibodies cause catatonia and seizures in rodents, providing a model for autoimmune encephalitis and supporting antibody depletion as a treatment.

Targeted rescue of synaptic plasticity improves cognitive decline in sepsis-associated encephalopathy

This study identifies synaptic pathomechanisms of sepsis-associated encephalopathy and demonstrates that targeted rescue of synaptic plasticity can improve cognitive decline in a mouse model.