Toni Kirmann

This study shows that autoantibodies against GABAB receptors cause presynaptic pathology leading to cognitive decline and memory impairment.

This study investigates how LGI1 autoantibodies enhance synaptic transmission by reducing Kv1 channel density and broadening presynaptic action potentials.

This study shows that LGI1-reactive monoclonal antibodies cause seizures in rats, with molecular and electrophysiological evidence of epileptogenesis.

This study develops NMDA-receptor-Fc-fusion constructs that neutralize anti-NMDA receptor antibodies and inhibit their effects on neurons.