Massimo Scanziani

A cognitive representation in primary visual cortex modulated by vision

The paper shows that path-invariant activity in V1 neurons is modulated by visual stimuli rather than replaced, linking V1 to a brain-wide network involved in learning.

Left-right alternation of superior colliculus activity with the stepping rhythm

The paper shows that superior colliculus neurons in mice fire at opposite phases of the stepping rhythm, supporting left-right turn coordination during locomotion.

Hippocampal representations of possible futures predict motor output in the superior colliculus

The paper shows that hippocampal representations of possible future paths predict motor output in the superior colliculus during navigation.

The Logic of Thalamic Inputs onto the Molecular Taxonomy of Cortical Neurons Reveals a Visual Hierarchy

The paper maps thalamic inputs onto molecularly defined cortical neurons in mice, revealing a visual hierarchy through bottom-up and top-down signatures.

Vision shapes neural maps of space through an ancient midbrain pathway

The paper shows that visual signals reach the hippocampus through a conserved midbrain pathway, enabling spatial maps even after visual cortex ablation.

Novel visuomotor adaptation paradigm reveals a role of visual cortex in the plasticity of innate behaviors in mice

This study develops a novel visuomotor adaptation paradigm in mice to investigate the role of visual cortex in behavioral plasticity, finding that V1 disruption impairs adaptation to visual field shifts.

Inter- and Intrahemispheric Sources of Vestibular Signals to V1

The paper identifies inter- and intrahemispheric sources of vestibular signals to V1, showing that the ipsilateral pulvinar and contralateral visual cortex provide head movement signals with specific directional biases.

The brain simulates actions and their consequences during REM sleep

This study shows that during REM sleep, the mouse brain issues motor commands that shift internal direction representations, simulating actions and their consequences without physical execution.

Brain state-dependent modulation of thalamic visual processing by cortico-thalamic feedback

This study shows that cortico-thalamic feedback is essential for state-dependent changes in dLGN neuron responses to visual stimuli in mice.

The combination of feedforward and feedback processing accounts for contextual effects in visual cortex

The paper develops a circuit model showing how feedforward and feedback processing in mouse V1 explain three contextual effects in visual responses.

Erasing motion: Scrambling direction selectivity in visual cortex during saccades

The paper shows that during saccades, mouse V1 distinguishes self-generated motion from external motion using pulvinar input.

A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex

The paper identifies a disinhibitory circuit in mouse visual cortex that modulates responses based on stimulus-surround similarity.

Head Movements Control the Activity of Primary Visual Cortex in a Luminance Dependent Manner

This study shows that mouse primary visual cortex processes head movements differently depending on ambient luminance, with SOM inhibitory neurons playing a key role in this light-dependent switch.

Neurons in Visual Cortex are Driven by Feedback Projections when their Feedforward Sensory Input is Missing

The paper identifies a feedback receptive field (fbRF) in mouse V1 neurons that is driven by feedback projections and complements the feedforward receptive field (ffRF) in predictive processing.

Visual physiology of the Layer 4 cortical circuit in silico

The paper develops a biophysically detailed in silico model of layer 4 of the mouse primary visual cortex, showing how functional synaptic connectivity reproduces experimental observations of neuronal responses to visual stimuli.

Emergence of Direction Selectivity at the Convergence of Thalamo-Cortical Synapses in Visual Cortex

The paper shows how thalamic neurons with distinct time-courses contribute to direction selectivity in mouse visual cortex through spatiotemporal integration.

First spikes in visual cortex enable perceptual discrimination

The paper shows that the first spikes in visual cortex are sufficient for perceptual discrimination in mice, with a threshold duration of 40-80 milliseconds.