Elizabeth C. Hamada

The paper shows that Scn2a loss-of-function in mice causes degraded sensory coding in the cortex, which is rescued by CRISPRa gene activation.

This study shows that CRISPR activation can rescue electrophysiological deficits in SCN2A haploinsufficiency by increasing the expression of the remaining functional allele in mice and human neurons.

The paper identifies inter- and intrahemispheric sources of vestibular signals to V1, showing that the ipsilateral pulvinar and contralateral visual cortex provide head movement signals with specific directional biases.

The paper identifies impaired cerebellar plasticity as a mechanism underlying hypersensitized sensory reflexes in SCN2A-associated ASD, showing that increasing Scn2a expression rescues VOR plasticity in mice.

This paper examines the ultrastructural characteristics of rod photoreceptors in the simplex retina of Little skate, finding a hybrid rod-cone morphology and enhanced synaptic connectivity that may explain their functional plasticity across lighting conditions.