Author

Penny P. Powell

University of East AngliaORCID 0000-0002-5347-0490Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Cell Biology· 1

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Thomas E. WilemaniD· 3 shared Agatha TreveiliD· 2 shared Emily J. JonesiD· 2 shared Federica Di PalmaiD· 2 shared Isabelle HautefortiD· 2 shared Lindsay J. HalliD· 2 shared Matthew A. JeffersoniD· 2 shared Padhmanand SudhakariD· 2 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSystems Biology

Thomas E. WilemanORCID

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3 papers

Recent·Most cited

ATG16L1 WD domain regulates lipid trafficking to maintain plasma membrane integrity to limit influenza virus infection

Benjamin Bone, Luke Griffith, Matthew A. Jefferson, Yohei Yamauchi, Thomas E. Wileman, Penny P. Powell

Autophagy · Mar 28, 2025Peer-reviewedCell Biology

Regulatory network analysis of Paneth cell and goblet cell enriched gut organoids using transcriptomics approaches

Agatha Treveil, Padhmanand Sudhakar, Z. J. Matthews, Tomasz Wrzesiński, Emily J. Jones, Johanne Brooks, Marton L. Olbei, Isabelle Hautefort, Lindsay J. Hall, Simon Richard Carding, Ulríke Mayer, Penny P. Powell, Thomas E. Wileman, Federica Di Palma, Wilfried Haerty, Tamas Douglas Korcsmaros

The paper uses transcriptomics and network analysis to study regulatory networks in Paneth and goblet cell enriched gut organoids, identifying key regulators and their links to inflammatory bowel disease.

Molecular Omics · Dec 10, 2019Peer-reviewedSystems Biology

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

Emily J. Jones, Zoe J. Matthews, Lejla Gul, Padhmanand Sudhakar, Agatha Treveil, Devina P Divekar, Jasmine Buck, Tomasz Wrzesiński, Matthew A. Jefferson, Stuart D. Armstrong, Lindsay J. Hall, Alastair J.M. Watson, Simon Richard Carding, Wilfried Haerty, Federica Di Palma, , Tamas Douglas Korcsmaros

The paper integrates proteomic and transcriptomic data from intestinal organoids to identify autophagy-dependent processes in Paneth cells, showing that autophagy impairment affects protein abundance and key cellular functions.

Disease Models & Mechanisms · Jan 1, 2019Peer-reviewedSystems Biology