Single Cell Analysis Reveals Multi-faceted miR-375 Regulation of the Intestinal Crypt
Michael T. Shanahan, Matt Kanke, Ajeet Pratap Singh, Jonathan Villanueva, Adrian J. McNairn, Oyebola O. Oyesola, Alessandro Bonfini, Yu-Han Hung, Breanna J. Sheahan, Jordana C. Bloom, Rebecca L. Cubitt, Ennessa G. Curry, Wendy A. Pitman, Vera D. Rinaldi, Christopher M. Dekaney, , Praveen Sethupathy
This study identifies miR-375 as a key regulator of intestinal crypt homeostasis, showing its role in stem cell proliferation, tuft cell abundance, and resistance to infection and cancer.
bioRxiv · Oct 1, 2020 · PreprintMolecular Biology