Jianming Lu

The paper reports a cryo-EM structure of the S2 fragment of SARS-CoV-2 after S2 cleavage, showing it represents a late fusion intermediate, and shows that S2 cleavage accelerates membrane fusion.

This paper introduces a no-wash, high-throughput toxicity assay using a novel fluorescent dye to measure mitochondrial membrane potential in primary cells and validates it with a compound screening.