Amy Y. Huang

Genomic, Clinical, and Spatial Predictors of Durable Response to BRAF/MEK Inhibition in BRAF-Mutant Melanoma

Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment

This study uses spatial multi-omics to compare EBV-positive and EBV-negative cHL, identifying distinct TME features and immunological signatures linked to EBV.

Harnessing Inflammatory Monocytes to Overcome Resistance to Anti-PD-1 Immunotherapy

This study shows CD40 agonist therapy reduces tumor growth in antigen presentation-deficient tumors by reprogramming monocytes and requiring IFN-gamma and CD8+ T cells for efficacy.

Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma

The paper identifies a mature dendritic cell subtype associated with improved immune response and prognosis in melanoma patients treated with anti-PD-1 checkpoint inhibitors.

Stratified analysis identifies HIF-2α as a therapeutic target for highly immune-infiltrated melanomas

The paper identifies HIF-2α as a therapeutic target for immune-infiltrated melanomas through stratified analysis of clinical and molecular data.

Effects of Host-Tree Foliage on Polymorphism in an Insect Pathogen

The paper measures fitness components of two baculovirus morphotypes and shows how host-tree species influence their coexistence through tradeoffs and environmental heterogeneity.

Cross-domain information fusion for enhanced cell population delineation in single-cell spatial-omics data

This paper introduces CellSNAP, a self-supervised method that integrates spatial, transcriptomic, and proteomic data to improve cell population delineation in spatial-omics datasets.