Patrick M. Dougherty

The paper investigates neurodegeneration in dorsal root ganglia across diabetes and diabetic painful neuropathy stages, identifying early molecular changes and highlighting the need for early intervention.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

This study examines suzetrigine's effects on human dorsal root ganglion neurons, showing it suppresses spontaneous pain-related discharges but requires longer exposure to affect evoked pain.

The paper shows OSM-OSMR signaling via MAPKs drives transcriptomic changes in human DRG linked to neuropathic pain.

The paper shows that MNK inhibitor eFT508 reduces spontaneous activity in human DRG neurons from painful dermatomes.

This study identifies periosteal nerve sprouting and DRG metastasis in MM-induced bone pain, linking these changes to pain mechanisms and suggesting neuroprotective strategies.

The paper profiles RNA in human DRGs from neuropathic pain patients, identifying sex-specific gene expression differences and neuro-immune pathways associated with pain.

The paper uses spatial transcriptomics to characterize human sensory neurons, comparing them to mouse and non-human primate data to identify similarities and divergences in drug targets.

The paper shows that human dorsal root ganglion neurons express ACE2, suggesting they may be a target for SARS-CoV-2 entry into the nervous system.

The paper identifies the RagA-mTORC1 network as a key driver of neuropathic pain through cell-specific translational profiling in nociceptors.