Author

Shannon G. MacLeod

Northeastern UniversityORCID 0000-0002-5455-045XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Tovah A. DayiD· 3 shared Adrianna L. VandeureniD· 2 shared Annika SalpukasiD· 2 shared Ella CheeiD· 2 shared Lindsay R. JulioiD· 2 shared Arne Nedergaard KousholtiD· 1 shared Charlotte H. WalborskyiD· 1 shared Diana V. Turrieta VejariD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

Tovah A. DayORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

G4 DNA structures induced by UV radiation: a multi-omic approach

Lindsay R. Julio, Diana V. Turrieta Vejar, Charlotte H. Walborsky, Annika Salpukas, Ella Chee, Julianne C. Murthy, Shannon G. MacLeod, Adrianna L. Vandeuren, Mynaja Ferguson, Rachel E. Muriph, Jason J. Evans, Tovah A. Day

This study identifies UV radiation-induced G4 DNA structures in human cells using multi-omic analyses and reveals their role in genotoxic stress responses.

bioRxiv · Jul 16, 2026 · PreprintCell Biology

The Role of BAZ2-dependent Chromatin Remodeling in Suppressing G4 DNA Structures and Associated Genomic Instability

Adrianna L. Vandeuren, Kierney O’Dare, Rosemary H. C. Wilson, Patrick van Eijk, Lindsay R. Julio, Shannon G. MacLeod, Ella Chee, Annika Salpukas, Emma M. Kriz, George A. Lantz, Shellaina J.V. Gordon, Simon J. Elsässer, Simon Huw Reed, Tovah A. Day

This study identifies BAZ2 chromatin remodelers as suppressors of G4 DNA structures and shows that their depletion increases G4 formation and genomic instability.

bioRxiv · Dec 10, 2024 · PreprintMolecular Biology

FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells

Ke Cong, Nathan J. MacGilvary, Silviana Lee, Shannon G. MacLeod, Jennifer A. Calvo, Min Peng, Arne Nedergaard Kousholt, Tovah A. Day, Sharon B. Cantor

The paper investigates how FANCJ helicase affects PARP1 activity during DNA replication in BRCA1 deficient cells, revealing its role in PARPi efficacy and resistance.

Nature Communications · Mar 23, 2024Peer-reviewedMolecular Biology