Simon Schenk

Cardiomyocyte Perm1 sustains cardiac bioenergetic reserve and exercise capacity

This study shows that Perm1 in cardiomyocytes is essential for maintaining cardiac bioenergetic reserve, affecting exercise capacity but not resting function.

Temporal Multi-Omic Analysis Uncovers Sex-Biased Molecular Programs Underlying Skeletal Muscle Adaptation to Endurance Training

This study identifies shared and sex-specific molecular responses to endurance training in skeletal muscle using multi-omics data from rats.

Systems modeling of mitochondrial dynamics in different exercise regimes

The paper develops a computational model to simulate how different exercise regimes affect mitochondrial fission and fusion dynamics in skeletal muscle.

Sexually distinct multi omic responses to progressive endurance exercise training in the rat lung. Findings from MoTrPAC

This study identifies sex-specific multi-omic responses to endurance exercise training in rat lungs, revealing differences in immune pathways and mitochondrial acetylation between males and females.

Markers of mitochondrial function and oxidative metabolism in female skeletal muscle do not display intrinsic circadian regulation

The study shows that mitochondrial function and oxidative metabolism markers in female mouse skeletal muscle lack intrinsic circadian regulation, despite core-clock genes showing rhythmicity.

Endurance exercise drives temporal and sexual dimorphic multi-omic adaptations in liver metabolism-Findings from MoTrPAC.

This study examines how endurance exercise affects liver metabolism in male and female rats over time, revealing sex-specific molecular changes and protective effects.

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue

This study examines how endurance exercise training affects rat subcutaneous white adipose tissue, revealing sex-specific molecular responses and differences in adiposity and metabolism.

Intrinsic skeletal muscle function and contraction-stimulated glucose uptake do not vary by time-of-day in mice

This study shows that intrinsic skeletal muscle function and contraction-stimulated glucose uptake in mice do not vary across the 24-hour circadian cycle.

The mitochondrial multi-omic response to exercise training across tissues

This study maps multi-omic mitochondrial changes across 19 tissues in rats after endurance exercise training, identifying tissue-specific adaptations and disease-related hubs.