This study identifies 118 new genetic loci associated with Alzheimer's disease across diverse ancestries and discovers 48 novel risk loci, including those enriched in neuronal cell types.

medRxiv · Oct 10, 2025 · PreprintGenetic & Genomic Medicine

Golgi Fragmentation - One of the Earliest Organelle Phenotypes in Alzheimer's Disease Neurons

Henriette Haukedal, Giulia Ilaria Corsi, Veerendra P. Gadekar, Nadezhda T. Doncheva, Shekhar Kedia, Noortje de Haan, Abinaya Chandrasekaran, Pia Jensen, Pernille Schiønning, Sarah Vallin, Frederik Ravnkilde Marlet, Anna Poon, Carlota Pires, Fawzi Khoder‐Agha, Hans Heugh Wandall, , Kristine Freude

The paper identifies Golgi fragmentation as an early AD phenotype in neurons using stem cell and mouse models, showing its link to SORL1 variants and glycosylation changes.

Frontiers in Neuroscience · Feb 16, 2023Peer-reviewedNeuroscience

Cerebrospinal fluid formation is controlled by membrane transporters to modulate intracranial pressure

Eva Kjer Oernbo, Annette Buur Steffensen, Pooya Razzaghi Khamesi, Trine Lisberg Toft‐Bertelsen, Dagne Barbuskaite, Frederik Vilhardt, Niklas J. Gerkau, Katerina Tritsaris, Anja Hviid Simonsen, Sara Diana Lolansen, Søren Norge Andreassen, Steen Gregers Hasselbalch, Thomas Zeuthen, Christine R. Rose, Vartan Kurtcuoglu, Nanna MacAulay

This study identifies membrane transporters involved in cerebrospinal fluid (CSF) secretion and shows their role in modulating intracranial pressure.

Fluids and Barriers of the CNS · Aug 29, 2022Peer-reviewedNeuroscience