Author

Jonah C Meltzer

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Bradley T. HymaniD· 2 shared Maryam A. Nishtar· 2 shared Rosemary J. JacksoniD· 2 shared Steven E. Dierksmeier· 2 shared Alexandra N. MelloniiD· 1 shared Beverly L. DavidsoniD· 1 shared Bobby BeaumontiD· 1 shared David M. HoltzmaniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Bradley T. HymanORCID

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2 papers

Recent·Most cited

Utilizing a cell culture based novel cellular thermal shift assay to understand the isoform-dependent thermal stability of ApoE variants

Rosemary J. Jackson, Steven E. Dierksmeier, Maryam A. Nishtar, Jonah C Meltzer, Frieda Balduin, Bobby Beaumont, Zhanyun Fan, Eduard A. Sergienko, Steve Olson, Michael R Jackson, Bradley T. Hyman

The paper develops BiTSA, a bioluminescence-based thermal stability assay, to characterize isoform-dependent thermal stability of ApoE variants in living cells and confirms that ApoE4 is less stable than ApoE3 in native tissue.

bioRxiv · Jun 11, 2026 · PreprintNeuroscience

APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease

Rosemary J. Jackson, Megan S. Keiser, Jonah C Meltzer, Dustin P. Fykstra, Steven E. Dierksmeier, Soroush Hajizadeh, Johannes Kreuzer, Robert Tyler Morris, Alexandra N. Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T. Ranum, Ellie M. Carrell, YongHong Chen, Maryam A. Nishtar, , Bradley T. Hyman

This paper shows that APOE2 gene therapy reduces amyloid deposition, neurodegeneration, and microglial activation in an Alzheimer's mouse model with ongoing APOE4 expression.

Molecular Therapy · Mar 18, 2024Peer-reviewedNeuroscience