Author

Tsuneo Nakajima

Harvard UniversityORCID 0000-0002-3670-1701Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Alexandra N. MelloniiD· 2 shared Bradley T. HymaniD· 2 shared Rosemary J. JacksoniD· 2 shared Alberto Serrano‐PozoiD· 1 shared Beverly L. DavidsoniD· 1 shared David M. HoltzmaniD· 1 shared Derek Oakley· 1 shared Desmond Owusu KwartengiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Alexandra N. MelloniORCID

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2 papers

Recent·Most cited

Lipidated ApoE is found in nanoscale proximity to Aβ aggregates in human Alzheimer brains.

Desmond Owusu Kwarteng, Rosemary J. Jackson, Tsuneo Nakajima, Kirstin Altig, Alexandra N. Melloni, Derek Oakley, Alberto Serrano‐Pozo, Masato Maesako, Bradley T. Hyman

The paper shows lipidated ApoE is closely located to Aβ aggregates in human Alzheimer's brains, suggesting a role in plaque formation.

bioRxiv · Jun 3, 2026 · PreprintNeuroscience

APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease

Rosemary J. Jackson, Megan S. Keiser, Jonah C Meltzer, Dustin P. Fykstra, Steven E. Dierksmeier, Soroush Hajizadeh, Johannes Kreuzer, Robert Tyler Morris, Alexandra N. Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T. Ranum, Ellie M. Carrell, YongHong Chen, Maryam A. Nishtar, , Bradley T. Hyman

This paper shows that APOE2 gene therapy reduces amyloid deposition, neurodegeneration, and microglial activation in an Alzheimer's mouse model with ongoing APOE4 expression.

Molecular Therapy · Mar 18, 2024Peer-reviewedNeuroscience