Ramendra N. Saha

This study shows the nBAF complex facilitates activity-induced transcription of IEGs by regulating RNA Polymerase II elongation through its assembly and ATPase activity.

The paper shows mild depolarization in neurons triggers immediate early genes and temporarily reduces responses to subsequent stimuli.

The paper identifies genetic variants in RGS14 that disrupt nuclear shuttling and impair LTP regulation in hippocampal neurons, with variant LR causing nuclear accumulation and loss of function.

The paper shows that distinct neuronal activity patterns induce different gene expression programs through specific mechanisms.