John R. Hepler

This study identifies structural elements of RGS14 that regulate hormone-sensitive phosphate transport by NPT2A, showing that phosphorylation in the linker and an intact PDZ ligand are essential.

This study shows that RGS14 suppresses cocaine-induced behavioral changes in female mice by modulating emotional-motivational circuits.

This study maps RGS14 protein expression in the adult mouse brain, revealing broader expression than previously known in regions involved in cognitive functions and behavior.

This study shows RGS14 protects hippocampal neurons from seizure-induced mitochondrial oxidative stress and pathology by modulating excitability and signaling.

This study investigates how RGS14 affects locomotor behavior and ERK signaling in response to environmental novelty and cocaine in specific limbic regions.

The paper identifies genetic variants in RGS14 that disrupt nuclear shuttling and impair LTP regulation in hippocampal neurons, with variant LR causing nuclear accumulation and loss of function.

This study shows RGS14 restricts synaptic plasticity in hippocampal CA2 by limiting postsynaptic calcium signaling and downstream pathways.

This study identifies CaM and CaMKII as novel interacting partners of RGS14 in mouse brain, revealing RGS14 as a CaM effector and CaMKII phosphorylation substrate.