Author

Kelsey M. Tyssowski

Harvard UniversityORCID 0000-0002-5324-4872Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Assay:electronic health records· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Jesse M. GrayiD· 3 shared Adam W. HantmaniD· 1 shared Anastasia Nizhnik· 1 shared Carissa J. DunniD· 1 shared Chao TaniD· 1 shared Crista Carty· 1 shared Deshawn C Eijogu· 1 shared Hopi E. HoekstraiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersNeuroscience

Jesse M. GrayORCID

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4 papers

Recent·Most cited

Evolutionary expansion of the corticospinal system is linked to dexterity in Peromyscus mice

Kelsey M. Tyssowski, Jeremy D. Cohen, Jian‐Zhong Guo, Phoebe R. Richardson, Karen E Cortina, Isobel H. Smith, Deshawn C Eijogu, Adam W. Hantman, Hopi E. Hoekstra

This study shows that forest mice have larger corticospinal tracts and greater dexterity compared to prairie mice, supporting the hypothesis that CSN number expansion enhances motor skills.

bioRxiv · Oct 16, 2025 · PreprintNeuroscience

Firing rate homeostasis occurs in the absence of neuronal activity-regulated transcription

Kelsey M. Tyssowski, Katherine C. Letai, Sam Rendall, Chao Tan, Anastasia Nizhnik, Pascal S. Kaeser, Jesse M. Gray

The paper shows that firing rate homeostasis in cultured mouse neurons occurs without activity-regulated transcription, challenging the hypothesis that transcription is required for this process.

Journal of Neuroscience · Oct 31, 2019Peer-reviewedNeuroscience

Blue light induces neuronal-activity-regulated gene expression in the absence of optogenetic proteins

Kelsey M. Tyssowski, Jesse M. Gray

The paper shows blue light induces neuronal-activity-regulated gene expression in cultured mouse neurons without optogenetic proteins, suggesting blue light is unsuitable for long-term optogenetic experiments measuring transcription.

bioRxiv · Mar 11, 2019 · PreprintNeuroscience

Distinct neuronal activity patterns induce different gene expression programs

Kelsey M. Tyssowski, Nicholas R. DeStefino, Jin-Hyung Cho, Carissa J. Dunn, Robert G. Poston, Crista Carty, Richard D. Jones, Sarah M Chang, Palmyra Romeo, Mary K. Wurzelmann, James M. Ward, Mark L. Andermann, Ramendra N. Saha, Serena M. Dudek, Jesse M. Gray

The paper shows that distinct neuronal activity patterns induce different gene expression programs through specific mechanisms.

Neuron · Apr 19, 2018Peer-reviewedNeuroscience