John Paul Donohue

The paper shows QKI competes with SF1 for branch point sequences, repressing splicing and causing lethality in yeast.

The paper proposes a mechanism by which intron-lariat spliceosomes convert lariats into circular RNAs, suggesting a role in intron transposition.

The paper studies how different introns respond to splicing inhibitors in a humanized yeast strain, revealing intron-specific sensitivity and the impact of BP sequence variation.

The paper identifies alternative splicing programs in three germ layers and shows Quaking's role in cardiac mesoderm specification through splicing regulation.

The paper identifies over 150 new spliced regions in yeast genomes, termed protointrons, which are not conserved and may represent early stages of intron evolution.

The paper investigates how Quaking isoforms Qk5 and Qk6 regulate each other's expression through post-transcriptional mechanisms, balancing their functions in splicing and translation.