Author

Rongzhen Tian

MRC Laboratory of Molecular BiologyORCID 0000-0002-5499-726XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

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Fabian B. H. RehmiD· 2 shared Jason W. ChiniD· 2 shared Kim C. LiuiD· 2 shared Askar A. KleefeldtiD· 1 shared Cicely F. Day· 1 shared Franz Leonard Böge· 1 shared Jakob BirnbaumiD· 1 shared Jérôme F. ZürcheriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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10 top collaborators · 39 mutual co-author links

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2 shared papersSynthetic Biology

Fabian B. H. RehmORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintFeb 24, 2026

A portable orthogonal replication system enables continuous gene evolution near the biological speed limit

Rongzhen Tian, Fabian B. H. Rehm, Matthew Kenneth…·Jason W. Chin

This paper introduces an improved orthogonal replication system in E. coli that enables rapid gene evolution with high mutation rates and demonstrates its application in evolving ethanol assimilation pathways.

2 citations

E. coliDNA methylation

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Synthetic BiologySciencePeer-reviewedJul 31, 2025

Escherichia coli with a 57-codon genetic code

Wesley E. Robertson, Fabian B. H. Rehm, Martin Spinck…·Jason W. Chin

This paper describes the creation of a synthetic Escherichia coli strain with a 57-codon genetic code by recoding 105 codons in a 4 Mb synthetic genome.

38 citationstop 1%

E. coliexperimental assay

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