Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis
Babajide A. Ojo, Ying Zhu, Lyong Heo, Sejal R. Fox, Yanli Qiao, Amanda Waddell, Maria E. Moreno‐Fernandez, Marielle Gibson, Tracy Tran, Ashley L. Dunn, Essam A. Elknawy, Neetu Saini, Javier A. López-Rivera, Senad Divanovic, Yuqin Dai, , Michael J. Rosen
This study uses patient-derived colon organoids to identify lipid-related metabolic dysfunction in pediatric ulcerative colitis and shows that PPAR-α inhibition can alleviate metabolic and inflammatory features.
Nature Communications · Dec 10, 2025Peer-reviewedPhysiology