Author

Joseph El-Ghoubaira

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Anthony V. Columbus· 1 shared Christopher J. BakkenistiD· 1 shared Daniel IvanoviD· 1 shared Frank P. VendettiiD· 1 shared Jan Hendrik BeumeriD· 1 shared Joshua J. DeppasiD· 1 shared Kate M. MacDonaldiD· 1 shared Katherine M. AirdiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Anthony V. Columbus

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1 paper

Recent·Most cited

Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy

Pinakin Pandya, Frank P. Vendetti, Joseph El-Ghoubaira, Sudipta Pathak, Joshua J. Deppas, Reyna Jones, Anthony V. Columbus, Yunqi Zhang, Daniel Ivanov, Ziyu Huang, Kate M. MacDonald, Shane M. Harding, Raquel Buj, Katherine M. Aird, Jan Hendrik Beumer, , Christopher J. Bakkenist

The paper shows that dU-rich cytoplasmic DNA inhibits STING-dependent immune responses and enhances anti-PD-L1 therapy efficacy in tumors.

bioRxiv · Apr 4, 2024 · PreprintCancer Biology