David R. Walt

Single-Molecule Imaging Reveals Differential Stability of Alpha-Synuclein Aggregates

This study uses single-molecule imaging to show that Parkinson's disease-associated alpha-synuclein aggregates are more stable than physiological multimers under dilution.

Attomolar fecal cytokine profiling reveals gut immune dynamics and disease states

The paper introduces DIGEST, an ultrasensitive digital immunoassay for quantifying host proteins in fecal samples, demonstrating its utility in tracking immune dynamics and predicting disease outcomes.

Identification of markers for the isolation of neuron-specific extracellular vesicles

The paper identifies NRXN3 as a neuron-specific marker for isolating extracellular vesicles from biofluids and develops methods to isolate these vesicles for neurological disease research.

Assessment of extracellular vesicle protein cargo as neurodegenerative disease biomarkers

This study develops methods to measure proteins inside extracellular vesicles and applies them to assess neurodegenerative disease biomarkers in plasma.

L1CAM is not Associated with Extracellular Vesicles in Human Cerebrospinal Fluid or Plasma

The paper shows L1CAM is not associated with extracellular vesicles in human plasma or CSF and provides tools to evaluate other markers for NDEV isolation.