William C. Budell

This study uses cryo-EM to determine the structure of a light-regulated bacterial two-component system, revealing how light affects signaling through changes in histidine kinase and response regulator interactions.

This study characterizes IDE conformational dynamics using cryo-EM and MD simulations, identifying key residues and mechanisms that modulate enzyme activity.

This study uses time-resolved cryo-EM to visualize early intermediates in bacterial RNA polymerase promoter melting, revealing key steps in the formation of the transcription-competent open complex.

This paper introduces CryoCycle, a method for blotting, vitrifying, and reusing clipped cryoEM grids to reduce costs and improve access to cryoEM.