Oliver D.K. Maddocks

This study uses [18F]FSPG to non-invasively monitor redox changes linked to ferroptosis in tumors and assess immunotherapy effectiveness.

The paper identifies glucuronidation pathway upregulation as a mechanism by which colon cancer cells develop resistance to trametinib, showing that inhibiting this pathway can reverse resistance in both Drosophila and mouse models.

This study shows that developmental mitochondrial complex I dysfunction reduces lifespan and stress resistance, while adult-onset dysfunction increases lifespan and stress resistance.

This study shows that pyruvate from bone marrow mesenchymal stem cells supports myeloma cell redox homeostasis and anabolism through MCT-1/2 transporters.

The paper shows that gut bacteria in Drosophila use metabolic cross-feeding to overcome poor diets and influence host behavior.