Dag Aarsland

This study identifies 118 new genetic loci associated with Alzheimer's disease across diverse ancestries and discovers 48 novel risk loci, including those enriched in neuronal cell types.

The paper identifies cardiotonic steroids as potential repurposing candidates for lithium treatment of severe depression based on transcriptional and epidemiological analyses.

The paper shows that synaptotoxic forms of amyloid-beta and alpha-synuclein act through the same Wnt/PCP pathway to cause dendritic spine loss in neurodegenerative diseases.

This study investigates the genetic relationship between depression symptoms and Alzheimer's disease using GWAS and finds significant genetic correlations but no causal link, suggesting proxy cases may drive the overlap.

This study identifies parieto-temporo-occipital cortical volume loss in Parkinson's Disease psychosis and links it to serotonergic receptor gene expression.

This study shows fasudil reverses gene expression patterns associated with neurodegenerative disease in Alzheimer's model mice.

This study investigates genetic overlap and causality between blood plasma proteins and Alzheimer's Disease using polygenic risk scores and Mendelian Randomization, finding associations but no strong causal links.

The paper evaluates an AI-based cognitive assessment tool for detecting cognitive impairment in MCI and AD patients, showing good validity and generalisability across populations.

This study shows that α-synuclein accumulation in presynaptic terminals causes synaptic dysfunction and progressive neurodegeneration in a Drosophila model, with similar findings in patient samples.

This study identifies seven novel genetic loci for Alzheimer's disease using a large GWAS and highlights microglia and immune pathways as key contributors to disease pathology.

The paper integrates lipidomics and proteomics data to identify modules associated with Alzheimer's disease phenotypes and risk loci in immune and lipid pathways.

This study finds a genetic link between schizophrenia polygenic risk and psychotic symptoms, particularly delusions, in Alzheimer's disease through a meta-analysis of 11 cohort studies.

This study identifies 9 novel genetic loci and 215 potential causative genes associated with Alzheimer's disease risk through a large genome-wide association analysis.