Luke R. Joyce

The DUF998 family protein DrmA modulates cationic glycolipid levels and the emergence of high-level daptomycin resistance in Enterococcus faecalis

This study identifies DrmA, a DUF998 family protein, as a regulator of cationic glycolipid levels and a contributor to high-level daptomycin resistance in E. faecalis.

Meningeal inflammation and arachnoid barrier breakdown in a mouse model of neonatal bacterial meningitis

This study shows that GBS infection increases arachnoid barrier permeability in neonatal mice, driven by cytokine production from fibroblasts and macrophages.

A murine model of adult gastrointestinal colonization by Group B Streptococcus

This study establishes a murine model of Group B Streptococcus colonization in the adult gastrointestinal tract and identifies the GBS capsule as a critical colonization factor.

Global genome analysis identifies glycolipids and lipoteichoic acid alanylation as contributors to Group B streptococcal diabetic wound infection

The paper identifies glycolipids and lipoteichoic acid alanylation as factors contributing to Group B streptococcal diabetic wound infection using a transposon mutant screen in a murine model.

Identification of Glyoxalase A in Group B Streptococcus and its contribution to methylglyoxal tolerance and virulence

This study identifies Glyoxalase A (gloA) in Group B Streptococcus as essential for methylglyoxal tolerance and virulence during infection.

Biosynthesis of mitis group streptococcal glycolipids and their roles in physiology and antibiotic susceptibility

This study investigates the biosynthesis and roles of glycolipids in mitis group streptococci, showing their importance in virulence and antibiotic resistance.

Formation and function of the meninges arachnoid barrier around the developing brain

The paper identifies Wnt-β-catenin signaling repression as key to arachnoid barrier cell specification in mouse meninges and shows its role in preventing pathogen entry during development.