Kelly S. Doran

The DUF998 family protein DrmA modulates cationic glycolipid levels and the emergence of high-level daptomycin resistance in Enterococcus faecalis

This study identifies DrmA, a DUF998 family protein, as a regulator of cationic glycolipid levels and a contributor to high-level daptomycin resistance in E. faecalis.

A fungal pathobiont promotes Streptococcus agalactiae vaginal persistence and pathogenesis through physical and metabolic interactions

This study shows that Candida albicans supports Group B Streptococcus vaginal persistence and pathogenesis through physical and metabolic interactions.

Akkermansia muciniphila Impacts Group B Streptococcus Vaginal Colonization

This study shows Akkermansia muciniphila promotes GBS aggregation and attachment to vaginal epithelial cells, alters GBS gene expression, and reduces vaginal persistence.

Meningeal inflammation and arachnoid barrier breakdown in a mouse model of neonatal bacterial meningitis

This study shows that GBS infection increases arachnoid barrier permeability in neonatal mice, driven by cytokine production from fibroblasts and macrophages.

A murine model of adult gastrointestinal colonization by Group B Streptococcus

This study establishes a murine model of Group B Streptococcus colonization in the adult gastrointestinal tract and identifies the GBS capsule as a critical colonization factor.

Collagen binding adhesin restricts Staphylococcus aureus skin infection

This study shows that collagen binding adhesin (Cna) in Staphylococcus aureus reduces skin infection severity by binding to C1q and limiting inflammation.

Global genome analysis identifies glycolipids and lipoteichoic acid alanylation as contributors to Group B streptococcal diabetic wound infection

The paper identifies glycolipids and lipoteichoic acid alanylation as factors contributing to Group B streptococcal diabetic wound infection using a transposon mutant screen in a murine model.

Characterization of the Cellular Immune Response to Group B Streptococcal Vaginal Colonization

This study investigates the cellular immune response to GBS vaginal colonization in mice, finding that neutrophils and γδ T cells contribute to host defense, while overall immune cell numbers remain stable.

Identification of Glyoxalase A in Group B Streptococcus and its contribution to methylglyoxal tolerance and virulence

This study identifies Glyoxalase A (gloA) in Group B Streptococcus as essential for methylglyoxal tolerance and virulence during infection.

A group B streptococcal type VII secreted LXG toxin mediates interbacterial competition and colonization of the female genital tract

This study identifies a GBS T7SS-secreted toxin, BltA, that mediates interbacterial competition and vaginal colonization by inhibiting Enterococcus faecalis in vitro and in vivo.

Formation and function of the meninges arachnoid barrier around the developing brain

The paper identifies Wnt-β-catenin signaling repression as key to arachnoid barrier cell specification in mouse meninges and shows its role in preventing pathogen entry during development.