Author

Peter M. Siegel

Institut du cancer Rosalind & Morris GoodmanORCID 0000-0002-5568-6586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Adrien OsakweiD· 1 shared Aldo Hernández-CorchadoiD· 1 shared Anie MonastiD· 1 shared Ariel MadrigaliD· 1 shared Ashot Harutyunyan· 1 shared Daina Zofija AvizonisiD· 1 shared David J. PapadopoliiD· 1 shared Elham MoslemiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Adrien OsakweORCID

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2 papers

Recent·Most cited

Single-cell gene programs define subtype identity and metastatic trajectories in renal cell carcinoma

Ariel Madrigal, Minjun Kim, Zohreh Mehrjoo, Tamiko Nishimura, Özge Saatci, Adrien Osakwe, Evelyn Zavacky, Elham Moslemi, Kate I. Glennon, Matthew Dankner, Sarah M. Maritan, Hellen Kuasne, Virginie Pilon, Anie Monast, Mustafa Soytaş, , Hamed Shateri Najafabadi

This study identifies 59 gene expression programs in RCC that reveal subtype identity and metastatic trajectories, including a metastatic signature linked to poor clinical outcomes.

medRxiv · Jul 16, 2026 · PreprintGenetic & Genomic Medicine

Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

David J. Papadopoli, Ranveer Palia, Predrag Jovanovic, Sébastien Tabariès, Emma Ciccolini, Valérie Sabourin, Sebastian Igelmann, Shannon McLaughlan, Lesley Zhan, HaEun Kim, Nabila Chekkal, Krzysztof J. Szkop, Thierry Bertomeu, Jibin Zeng, Julia Avian Vassalakis, , Ivan Topisirović

This study shows that mitochondrial ETF insufficiency promotes cancer growth by reprogramming bioenergetics and signaling pathways in neoplastic cells.

eLife · May 5, 2026Peer-reviewedCancer Biology