Sebastian Igelmann

This study identifies a lactate-fueled metabolon involving LDHB and HTC that promotes breast cancer metastasis by reprogramming NAD metabolism.

This study shows that mitochondrial ETF insufficiency promotes cancer growth by reprogramming bioenergetics and signaling pathways in neoplastic cells.

The paper shows that the retinoblastoma protein (RB) prevents ribosomal readthrough during oncogene-induced senescence, acting as a caretaker tumor suppressor.

The paper identifies senescent cells in transient structures of developing amphibians and fish, suggesting an early evolutionary role of senescence in morphogenesis.