Erik Clark

The paper introduces a toolkit to analyze cell identity patterning by comparing cells to their neighbors, revealing Notch-dependent heterogeneity in neuromesodermal progenitors.

The paper identifies 11 new regulatory interactions governing timer gene expression in Drosophila embryos, showing how a dynamic Tailless gradient modulates their cross-regulatory module to define the tail region.

The paper uses coarse-grained models to study segmentation mechanisms in arthropods and vertebrates, finding that patterning depends on whether the segment addition zone is regulated by temporal or spatial information.

The paper shows that Caudal, Dichaete, and Odd-paired regulate segmentation timing in both Drosophila and Tribolium, with different temporal dynamics in long-germ and short-germ insects.

The paper shows that a damped oscillator mechanism drives posterior gap gene expression shifts in Drosophila, suggesting similarities between long- and short-germband segmentation.

The paper constructs a logical model of the Drosophila pair-rule gene network that simulates dynamic gene expression patterns and explains both long-germ and short-germ segmentation mechanisms.