The paper develops a 3D human iPSC-derived BrainSphere model on hdMEAs to screen for developmental neurotoxicity by measuring neural network activity and disruption from chemical exposures.

1 citation

humanspatial transcriptomics

𝕏 PostBluesky

NeuroscienceToxicological SciencesPeer-reviewedJul 12, 2024

Developmental origins of Parkinson's disease risk: perinatal exposure to the organochlorine pesticide dieldrin leads to sex-specific DNA modifications in critical neurodevelopmental pathways in the mouse midbrain

Joseph J. Kochmanski, Mahek Virani, Nathan C. Kuhn…·Alison I. Bernstein

This study shows that developmental exposure to dieldrin causes sex-specific DNA modifications in neurodevelopmental pathways, potentially increasing Parkinson's disease risk later in life.

21 citationstop 4%

mouseDNA methylation

𝕏 PostBluesky

NeuroscienceToxicological SciencesPeer-reviewedAug 22, 2023

Developmental exposure to the Parkinson's disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice

S. Boyd, Nathan C. Kuhn, Joseph R. Patterson…·Alison I. Bernstein

This study shows that developmental exposure to dieldrin worsens dopamine-related deficits in mice with synucleinopathy, suggesting environmental factors contribute to Parkinson's disease progression.

21 citations

mouseexperimental assay

𝕏 PostBluesky