Author

Reini E.N. van der Welle

Utrecht UniversityORCID 0000-0002-5591-2846Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Judith KlumpermaniD· 2 shared Fried J. T. ZwartkruisiD· 1 shared Jan van der BeekiD· 1 shared Judith J M JansiD· 1 shared Nalan LiviD· 1 shared Nanda M. Verhoeven‐DuifiD· 1 shared Paolo SanzàiD· 1 shared Rebecca JarkiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

Judith KlumpermanORCID

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2 papers

Recent·Most cited

VPS41 loss triggers iron overload, oxidative stress, and mitochondrial fragmentation linked to ferroptosis

Reini E.N. van der Welle, Rebecca Jark, Judith J M Jans, Nanda M. Verhoeven‐Duif, Judith Klumperman

This study shows that VPS41 loss causes iron overload, oxidative stress, and mitochondrial fragmentation, leading to ferroptosis and neurodegeneration.

bioRxiv · May 17, 2026 · PreprintCell Biology

HOPS is required for non-canonical mTORC1 signaling by recruiting Rags and FLCN to lysosomal membranes

Reini E.N. van der Welle, Jan van der Beek, Paolo Sanzà, Fried J. T. Zwartkruis, Nalan Liv, Judith Klumperman

This study shows that the HOPS complex recruits Rags and FLCN to lysosomal membranes, enabling non-canonical mTORC1 signaling and lysosomal biogenesis.

bioRxiv · May 15, 2026 · PreprintCell Biology