Author

Gurdyal Singh Besra

University of BirminghamORCID 0000-0002-5605-0395Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Apoorva BhattiD· 2 shared Alistair K. BrowniD· 1 shared Ana M. Xet-MulliD· 1 shared Anchal Malik· 1 shared Bhupesh TanejaiD· 1 shared Catherine VilchèzeiD· 1 shared Christos G. SavvaiD· 1 shared Clare M. SmithiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

Apoorva BhattORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 25, 2026

Polyketide synthase 12 is an in vivo essential source of novel mycolyl lipids in Mycobacterium tuberculosis

Gregory H. Babunovic, Sanne van der Niet, Marco Túlio Pardini Gontijo…·David Branch Moody

The paper identifies pks12 as an in vivo essential gene in Mtb by combining genomic, metabolomic, and phenotypic analyses, revealing its role in mycolyl lipid synthesis and host-pathogen interface structure.

DOI 10.64898/2026.09.25.754250

humanmouse

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MicrobiologyMicrobiologyPeer-reviewedOct 16, 2024

CryoEM structure of the di-domain core of Mycobacterium tuberculosis polyketide synthase 13, essential for mycobacterial mycolic acid synthesis.

Hannah E. Johnston, Sarah M. Batt, Alistair K. Brown…·Klaus Fütterer

This paper reports the cryoEM structure of M. tuberculosis Pks13, revealing its homodimeric architecture and providing insights into its catalytic mechanism.

3 citations

cryo-EMexperimental assay

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Molecular BiologyFASEB BioAdvancesPeer-reviewedMar 25, 2019

A novel mutation alters the stability of PapA2 resulting in the complete abrogation of sulfolipids in clinical mycobacterial strains

Vipul Navinchandra Panchal, Nidhi Jatana, Anchal Malik…·Vivek Rao

The paper identifies a mutation in the papA2 gene of Mycobacterium tuberculosis that leads to loss of sulfolipids by disrupting protein stability and structure.

11 citations

humanwhole-genome sequencing

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