Author

Michael J. Edel

The University of Western AustraliaORCID 0000-0002-5619-8680Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Alícia GarridoiD· 1 shared Ángel RayaiD· 1 shared Angelique di DomenicoiD· 1 shared Antonella ConsiglioiD· 1 shared Belén Álvarez-PalomoiD· 1 shared Dana Zhang· 1 shared Danial RoshandeliD· 1 shared E. N. WongiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Alícia GarridoORCID

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2 papers

Recent·Most cited

Accelerated Limbal Epithelial Differentiation of Human Induced Pluripotent Stem Cells Using a Defined Keratinocyte Serum-Free Medium

Danial Roshandel, Belén Álvarez-Palomo, Khine Zaw, Dana Zhang, Michael J. Edel, E. N. Wong, Steven J. Wiffen, Fred Kuanfu Chen, William Huxley Morgan, Samuel McLenachan

This study differentiates human induced pluripotent stem cells into limbal epithelial stem cells using a defined serum-free medium, showing increased expression of LESC markers by day 10.

bioRxiv · Aug 6, 2024 · PreprintBioengineering

Immunosuppressive tocilizumab prevents astrocyte induced neurotoxicity in hiPSC-LRRK2 Parkinson's disease by targeting receptor interleukin-6

Meritxell Pons‐Espinal, Lucas Blasco-Agell, Irene Fernández‐Carasa, Pol Andrés‐Benito, Angelique di Domenico, Yvonne Richaud‐Patín, Valentina Baruffi, Laura Marruecos, Lluı́s Espinosa, Alícia Garrido, EDUARDO S. TOLOSA, Michael J. Edel, Manel Juan, José Luis Mosquera, Isidró Ferrer, , Antonella Consiglio

The paper shows that tocilizumab, an IL-6 receptor inhibitor, prevents astrocyte-induced neurotoxicity in Parkinson's disease by blocking IL-6 signaling in neurons.

JCI Insight · Feb 8, 2024Peer-reviewedNeuroscience