Phospholipid Scramblases TMEM16F and Xkr8 regulate distinct features of Phosphatidylserine (PS) externalization and immune regulation in the tumor microenvironment to regulate tumor growth
Varsha Gadiyar, Rachael Pulica, Ahmed Aquib, James A. Tranos, Christopher Varsanyi, Trevor Frederick, Ziren Wang, Luis Fernandez Almansa, Lawrence D. Gaspers, Mariana S. De Lorenzo, Sergei V. Kotenko, Sushil Tripathi, Roger W. Howell, Alok Kumar Choudhary, David C. Calianese, Raymond B. Birge
This study shows that Xkr8 and TMEM16F regulate distinct PS externalization mechanisms in the tumor microenvironment, influencing immune evasion and tumor growth.
Cell Death Discovery · Nov 6, 2025Peer-reviewedCancer Biology