Tiffany Tsou

D-SPIN constructs gene regulatory network models from multiplexed scRNA-seq data revealing organizing principles of cellular perturbation response

Improved vector toolkit for genome writing in mammalian cells

The paper introduces an improved plasmid toolkit to streamline the mSwAP-In method for large-scale genome writing in mammalian cells.

Tunable population diversity through a noise-driven differentiation switch

The paper identifies a noise-driven differentiation switch mechanism that controls cell type diversity in neural progenitor cells through combinatorial signaling inputs.

Control of odor sensation by light and cryptochrome in the Drosophila antenna

This study shows that light and cryptochrome modulate odor aversion in Drosophila by affecting TRPA1 channel activity through reactive oxygen species.

Dissecting heterogeneous cell-populations across drug and disease conditions with PopAlign

PopAlign identifies subpopulations and tracks gene expression changes in heterogeneous cell mixtures across drug and disease conditions.

Designing signaling environments to steer transcriptional diversity in neural progenitor cell populations

The paper shows that signaling environments can control the diversity of neural progenitor cell populations in culture using single-cell RNA-seq and computational analysis.

Transcriptomic Description of an Endogenous Female State in C. elegans

The paper studies transcriptomic changes in C. elegans during the transition to an endogenous female state and finds that sperm loss drives some aging-related gene expression changes.