Isak Martinsson

Preferential generation of pathological tau species in specific subtypes of entorhinal neurons: implications for Alzheimer's Disease.

The paper investigates differential susceptibility of entorhinal neuronal subtypes to pathological tau species in Alzheimer's Disease, finding that ECLIII neurons show greater vulnerability than ECLII fan cells.

Neuronal age drives β-sheet accumulation and, together with ApoE4, enhances synaptic Aβ localization in APPNL-F neurons

The paper shows that neuronal age and ApoE4 genotype increase synaptic Aβ accumulation and alter its structural form in APPNL-F neurons.

Apolipoprotein E intersects with amyloid-β within neurons

The paper shows that ApoE4 increases Aβ42 levels in neurons and demonstrates intracellular intersection of ApoE with APP/Aβ in AD transgenic neurons.

Aβ/APP-induced hyperexcitability and dysregulation of homeostatic synaptic plasticity in models of Alzheimer's disease

This study shows that APP and Aβ increase neuronal hyperexcitability and impair homeostatic synaptic and intrinsic plasticity in Alzheimer's disease models.

FRET-based screening in HEK293T identifies p38 MAPK and PKC inhibition as therapeutic targets for α-synuclein aggregation