Author

James R. Partridge

University of California, San FranciscoORCID 0000-0002-5652-4351Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Assay:proteomics· 1

Frequent Co-Authors

Aayami Jain· 1 shared Adam R. RensloiD· 1 shared Alicia RichardsiD· 1 shared Amy DialloiD· 1 shared Angelica Garcia· 1 shared Annemarie F. CharvatiD· 1 shared B. Joy Quejarro· 1 shared Beeke WienertiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Aayami Jain

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2 papers

Recent·Most cited

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus-MPro inhibitors with potent in vivo efficacy

Tyler C. Detomasi, Gilles Degotte, Sijie Huang, Rahul K. Suryawanshi, Amy Diallo, Luca Lizzadro, Francisco José Zapatero Belinchón, Taha Y. Taha, Jiapeng Li, Alicia Richards, Eric R. Hantz, Zain Alam, Mauricio Montaño, Maria McCavitt-Malvido, Rajesh Gumpena, , Charles S. Craik

This paper describes the discovery of new coronavirus MPro inhibitors with improved pharmacokinetics, broad-spectrum antiviral activity, and superior in vivo efficacy compared to existing drugs.

Science Advances · Apr 23, 2025Peer-reviewedBiochemistry

Functional Screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair

Juan A. Pérez-Bermejo, Oghene Efagene, William M. Matern, Jeffrey K. Holden, Shaheen Kabir, Glen M. Chew, Gaia Andreoletti, Eniola Catton, Craig L. Ennis, Angelica Garcia, Trevor L. Gerstenberg, Kaisle A. Hill, Aayami Jain, Kristina Krassovsky, Cassandra D. Lalisan, , Kristen L. Seim

The paper identifies optimized protein-based enhancers of HDR in human HSPCs through functional screening, improving HDR efficiency without increasing off-target effects.

Nature Communications · Mar 23, 2024Peer-reviewedMolecular Biology