Lothar Jänsch

This paper identifies LemA proteins as conserved drivers of bacterial membrane reorganization, involved in organelle and vesicle formation through interactions with divisome components and other membrane remodeling factors.

The paper structures the Wza-Wzc complex from E. coli K12 using cryo-EM, revealing its role in CPS transport and identifying a CPS-binding domain.

This paper identifies PrdH as the maturation enzyme required for the formation of the pyruvoyl group in the proline reductase Prd of C. difficile, essential for proline utilization and toxin production.

This paper identifies M35 as a viral protein that binds DNA and inhibits IRF3-mediated gene expression, including Ifnb1, thereby suppressing the antiviral type I IFN response.

The paper establishes a mouse line for cell-type specific proteomic labeling and identifies regional astrocyte proteome differences using mass spectrometry.

The paper presents a proteogenomics workflow to identify small proteins in Staphylococcus aureus, finding 185 SP100, 69 of which were previously unannotated.