The paper identifies eicosanoid-enriched follicular microenvironments in HIV-infected individuals on antiretroviral therapy that may influence antibody responses and viral reservoir persistence.

bioRxiv · Sep 14, 2026 · PreprintImmunology

Plasma metabolomics reveals lipid-predominant metabolic disruptions in virologically suppressed people with HIV

Christopher M. Basting, Candace Guerrero, Kevin Escandón-Vargas, Jodi L. Anderson, Garritt Wieking, Erik Swanson, Ty Schroeder, Charlotte R. Hemmila, Ross T. Cromarty, Fernanda Torres-Ruiz, Maribel Soto-Nava, Lady Ruiz-Carbajal, Karla Krystel Ordaz-Candelario, Olivia Briceño, Nicholas Funderburg, , Nichole R. Klatt

The paper uses metabolomics to show that HIV-treated individuals have metabolic disruptions, including lipid changes and inflammation markers, despite viral suppression.

bioRxiv · Aug 20, 2026 · PreprintMicrobiology

A unified network systems approach uncovers a core novel program underlying T follicular helper cell differentiation

Alisa A. Omelchenko, Syed Ashiqur Rahman, Alyson Wang, Tracy Tabib, Vinay Viswanadham, Grace J. Yuen, Perla M. Del Río Estrada, Valentino D’Onofrio, Yijia Chen, Na Sun, Hamid Mattoo, Swapnil Keshari, Chinmay V. Gadiraju, Gonzalo Salgado Montes de Oca, Maribel Soto-Nava, , Jishnu Das

This study identifies a core gene program underlying Tfh cell differentiation using a multi-scale network systems approach, revealing a novel role for IL-12 in regulating Tfh precursor differentiation.

Nature Communications · Jul 22, 2026Peer-reviewedImmunology

Multi-omics links microbial dysbiosis, systemic inflammation and metabolomic disruptions to SNAE risk in treated HIV

Christopher M. Basting, Jodi L. Anderson, Kevin Escandón-Vargas, Garritt Wieking, Candace Guerrero, Jarrett Reichel, Ross T. Cromarty, Erik Swanson, Ty Schroeder, Elaina Creagan, Maura Barrett, Fernanda Torres-Ruiz, Maribel Soto-Nava, Lady Ruiz-Carbajal, Karla Krystel Ordaz-Candelario, , Nichole R. Klatt

This study links microbial dysbiosis, systemic inflammation, and metabolomic disruptions to SNAE risk in treated HIV patients through multi-omic analysis.

JCI Insight · Jul 21, 2026Peer-reviewedImmunology