Jonathan M. Franks

This study shows that loss of TFAM in alveolar type 2 cells leads to mitochondrial dysfunction and fibrosis by promoting senescence and a profibrotic secretory program.

This paper introduces SISTM to map 3D synaptic nanoarchitecture in brain tissue across species using cryo-ET and STA, revealing conserved structural features in human postmortem tissue.

This study investigates the organization and response of the keratin network in bladder umbrella cells to mechanical stress, revealing a tile-like structure dependent on plectin.

The paper introduces a cryo-FIB workflow to image brain tissue via in situ cryo-EM, enabling visualization of subcellular structures in fresh, unfixed mouse and postmortem human brain tissue.