Rafael C. Casellas

Highly Constrained Kinetic Models for Single-Cell Gene Expression Analysis

This study introduces a kinetic model that integrates scRNA-seq and imaging data to simulate gene transcription dynamics and identifies conserved quantities and improved models for transcription factor mechanisms.

Multifaceted roles of cohesin in regulating transcriptional loops

This study investigates cohesin's role in transcriptional loops and DNA replication using human cells, finding that cohesin loss affects long-range chromatin interactions and up-regulates early initiation zone genes.

Neuronal Enhancers are Hotspots For DNA Single-Strand Break Repair

The paper identifies DNA single-strand breaks (SSBs) accumulating at neuronal enhancers and shows their repair involves PARP1, XRCC1, and DNA polymerase β.

Super-resolution Imaging Reveals 3D Structure and Organizing Mechanism of Accessible Chromatin

This study uses super-resolution imaging to reveal the 3D structure and organizing mechanism of accessible chromatin domains.

Cohesin Loss Eliminates All Loop Domains, Leading To Links Among Superenhancers And Downregulation Of Nearby Genes

This study shows that cohesin loss eliminates loop domains, causing superenhancer links and gene downregulation, which are reversible upon cohesin restoration.