Author

Joel Chappell

Leuven Stem Cell InstituteORCID 0000-0002-5834-4100Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Developmental Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Vincent PasqueiD· 3 shared Adrian JaniszewskiiD· 2 shared Lotte VanheeriD· 2 shared San Kit ToiD· 2 shared Adrien RihouxiD· 1 shared Alejandro SifrimiD· 1 shared Alison KerremansiD· 1 shared Andréa Alex SchiavoiD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersDevelopmental Biology

Vincent PasqueORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A multi-omics genome-and-transcriptome single-cell atlas of human preimplantation embryogenesis reveals the cellular and molecular impact of chromosome instability

Elia Fernandez Gallardo, Alejandro Sifrim, Joel Chappell, Jonas Demeulemeester, Jennifer Clara Herrmann, Robin Vermotte, Alison Kerremans, Michiel Van der Haegen, Jens Van Herck, Sebastiaan Vanuytven, Katy Vandereyken, Iain C. Macaulay, Joris Robert Vermeesch, Karen Peeraer, Sophie Debrock, , Thierry Voet

This study uses single-cell genome-and-transcriptome sequencing to analyze the impact of chromosome instability on cellular states and development in human preimplantation embryos.

bioRxiv · Mar 8, 2023 · PreprintDevelopmental Biology

Predicting the Key Regulators of Cell Identity in Human Adult Pancreas

Lotte Vanheer, Federica Fantuzzi, San Kit To, Andréa Alex Schiavo, Matthias Van Haele, Tine Haesen, Xiaoyan Yi, Adrian Janiszewski, Joel Chappell, Adrien Rihoux, Toshiaki Sawatani, Tania Roskams, François N. Pattou, Julie A. Kerr-Conte, Miriam Cnop, Vincent Pasque

The paper reconstructs gene regulatory networks in human adult pancreatic cell types and identifies key transcription factors regulating cell identity.

bioRxiv · Sep 23, 2020 · PreprintBioinformatics

Dynamic Erasure of Random X-Chromosome Inactivation during iPSC Reprogramming

Adrian Janiszewski, Irene Talón, Joel Chappell, Samuel Collombet, Juan Song, Natalie De Geest, San Kit To, Greet Bervoets, Oskar Marín-Béjar, Caterina Provenzano, Lotte Vanheer, Jean‐Christophe Marine, Florian Rambow, Vincent Pasque

This study investigates the dynamics of X-chromosome reactivation during mouse iPSC reprogramming, revealing hierarchical gene activation patterns and the role of chromatin regulators.

bioRxiv · Feb 9, 2019Developmental Biology