GSAP regulates mitochondrial function through the Mitochondria-associated ER membrane in the pathogenesis of Alzheimer's disease
Peng Xu, Jerry C. Chang, Xiaopu Zhou, Wei Wang, Michael A. Bamkole, Eitan Wong, Karima Bettayeb, Lu-Lin Jiang, Timothy Y. Huang, Wenjie Luo, Huaxi Xu, Angus Clark Nairn, Marc Flajolet, Nancy Y. Ip, Yue‐Ming Li, Paul Greengard
This study identifies GSAP's role in Alzheimer's disease by showing it regulates mitochondrial function through the MAM and lipid homeostasis, with a SNP linked to increased AD risk.
The Journal of Experimental Medicine · May 27, 2021Peer-reviewedNeuroscience