Michael Downey

This study identifies Sky1 as a regulator of polyphosphate homeostasis in yeast, showing its role in controlling polyP levels and linking it to potassium homeostasis and gene expression.

The paper identifies 7 novel polyP-binding proteins in E. coli linked to translation control and ribosome biogenesis, with specific roles for YihI and Rnr.

This study shows Sfp1 and NuA4 interact in a TORC1-dependent manner to regulate ribosome biogenesis gene transcription through distinct mechanisms.

The paper uses proteomics to show that E. coli polyphosphate kinase (PPK) regulates lipid A modifications and polymyxin resistance during starvation by affecting the BasS/BasR two-component system.

The paper investigates how Ddp1 and Ppx1 counter polyphosphate toxicity in yeast by analyzing stress responses and enzyme functions.

The paper shows that the AP-3 complex is required for Vtc5 localization to the vacuole membrane in yeast, and its mislocalization leads to decreased polyP levels.

This study shows that internally produced polyP in human cells activates signaling pathways and alters gene and protein expression through ectopic expression of a bacterial polyP synthetase.

The paper identifies 8 new polyphosphorylated proteins in yeast, including vacuolar proteins, and suggests a feedback regulation model for polyP synthesis.

The paper uses synthetic biology in yeast to show a shared sequence determines substrate selection for Gcn5 and sirtuins and identifies subunits of the Gcn5 complex that regulate non-histone acetylations.