Jiehuan Sun

Association of polygenic risk scores with low-density lipoprotein cholesterol levels and control: findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

This study evaluates polygenic risk scores (PRS) for LDL cholesterol in a diverse Hispanic/Latino population, finding that some PRS improve prediction across subgroups but statin effectiveness varies with genetic ancestry.

Differential prediction performance between Caribbean- and Mainland-subgroups using state-of-the-art polygenic risk scores for coronary heart disease: Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

This study evaluates polygenic risk scores for coronary heart disease in Hispanic/Latino subgroups, finding better performance in Mainland compared to Caribbean subgroups.

A repurposed, blood gene signature is associated with poor outcomes in SARS-CoV-2

The paper identifies a blood gene signature predictive of poor outcomes in SARS-CoV-2 infection by analyzing its cellular sources in single-cell data.

sureLDA: A Multi-Disease Automated Phenotyping Method for the Electronic Health Record

sureLDA automates phenotype labeling in EHR data using topic modeling, achieving high accuracy and robustness across various phenotypes.

High-throughput Multimodal Automated Phenotyping (MAP) with Application to PheWAS

This paper develops an automated high-throughput phenotyping method (MAP) that improves phenotype accuracy and scalability for PheWAS studies.