Jianwen Cai

Old vs. New Local Ancestry Inference in HCHS/SOL: A Comparative Study

This study compares old and new local ancestry inference methods in Hispanic/Latino populations using HCHS/SOL data, finding high similarity but some regional discrepancies.

Differential prediction performance between Caribbean- and Mainland-subgroups using state-of-the-art polygenic risk scores for coronary heart disease: Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

This study evaluates polygenic risk scores for coronary heart disease in Hispanic/Latino subgroups, finding better performance in Mainland compared to Caribbean subgroups.

Multi-ancestry genome-wide analysis identifies common genetic variants for self-reported sleep duration and shared genetic effects

The paper identifies common genetic variants for sleep duration across multiple ancestries and finds shared genetic effects in diverse populations.

An integrated multi-omics analysis of sleep-disordered breathing traits across multiple blood cell types

The paper integrates multi-omics data to analyze how sleep-disordered breathing traits affect gene expression, metabolites, and potential causal pathways across blood cell types.

Admixture mapping screening of CKD traits and risk factors in U.S. Hispanic/Latino individuals from Central America country-of-origin

The paper identifies ancestry-derived loci associated with CKD traits and risk factors in U.S. Hispanic/Latino individuals of Central American origin using admixture mapping.

Polygenic Risk Scores for Alzheimer's Disease and Mild Cognitive Impairment in Hispanics/Latinos in the U.S: The Study of Latinos - Investigation ofNeurocognitive Aging

The paper evaluates polygenic risk scores for Alzheimer's Disease and Mild Cognitive Impairment in Hispanics/Latinos, finding that PRS based on AD GWAS predict MCI, with APOE region SNPs driving the association.

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

This study uses TOPMed whole genome sequences to improve imputation quality and detect rare variant associations in admixed African and Hispanic/Latino populations, identifying two novel associations with hematological traits.

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

This study identifies 93 genetic loci associated with kidney function across four ancestry groups and highlights causal effects on kidney-related diseases.