Author

Johannes Wagener

Trinity College DublinORCID 0000-0002-5952-9422Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Organism:fungi (other)· 2 Approach:genetic perturbation / CRISPR· 2 Organism:Arabidopsis· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1

Frequent Co-Authors

Sean Brazil· 3 shared Hesham Elsaman· 2 shared Karl DichtliD· 2 shared Christoph MülleriD· 1 shared Dominik Ruf· 1 shared Evgeny GolubtsoviD· 1 shared Isabel KlugherziD· 1 shared Isabel Kopp-Fouquet· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersMicrobiology

Sean Brazil

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Rho2-dependent cell wall remodeling boosts the fungistatic activity of manogepix against Aspergillus fumigatus

Sean Brazil, Isabel Kopp-Fouquet, Samuel Zen Kai Yap, Michael Carty, Johannes Wagener

This study shows that Rho2-dependent cell wall remodeling enhances manogepix's fungistatic effect against Aspergillus fumigatus by reducing cell wall chitin upregulation.

The Cell Surface · Dec 14, 2025Peer-reviewedMicrobiology

Rho2 regulates granulocyte-triggered stress adaptation and cell wall remodeling in Aspergillus fumigatus

Dominik Ruf, Kristina Striegler, Sean Brazil, Hesham Elsaman, Kalpana Singh, Mathieu Lepas, Liyanage Devthilini Pasasum Fernando, Victor Brantl, Patricia Heß, Karl Dichtl, Vishukumar Aimanianda, Tuo Wang, Johannes Wagener

This study shows Rho2 in Aspergillus fumigatus enhances cell wall remodeling and stress resistance against granulocyte attacks, improving survival through upregulation of cell wall biosynthesis.

Microbiological Research · May 23, 2025Peer-reviewedMicrobiology

Toxic eburicol accumulation drives the antifungal activity of azoles against Aspergillus fumigatus

Hesham Elsaman, Evgeny Golubtsov, Sean Brazil, Natanya Ng, Isabel Klugherz, Ronny Martin, Karl Dichtl, Christoph Müller, Johannes Wagener

This study identifies eburicol accumulation as the mechanism by which azoles exert fungicidal effects against Aspergillus fumigatus, distinct from their action in yeasts.

Nature Communications · Jul 26, 2024Peer-reviewedMicrobiology