Tuo Wang

Therapeutic vulnerabilities of the drug-resistant fungal meningitis pathogen Cryptococcus neoformans

This study identifies therapeutic vulnerabilities in Cryptococcus neoformans using CRISPR-insert and machine learning, revealing new drug targets and synthetic lethal dependencies.

Oxidative Stress-Responsive Cell Wall Remodeling Depends on Phosphate in Candida albicans

This study shows that phosphate availability influences cell wall remodeling in C. albicans under oxidative stress, linking nutrient sensing to fungal mechanical resilience.

A Glucan Synthase-Remodeler Module Organizes Branched Glucan Assembly in the Fungal Cell Wall

This study identifies Ghs2 as a binding partner of Bgs3 in fission yeast, showing they co-localize and work together to synthesize and branch β-1,3-glucan in the fungal cell wall.

Distinguishing Polymer Turnover from De Novo Biosynthesis Reveals Dynamic Cell Wall Remodeling During Aspergillus fumigatus Conidial Germination

The paper distinguishes polymer turnover from de novo biosynthesis in Aspergillus fumigatus during conidial germination using isotope-edited solid-state NMR, revealing dynamic cell wall remodeling.

Perturbing glycosylphosphatidylinositol (GPI)-anchor biosynthesis alters cell wall architecture and modulates fungal morphology

This study shows that disrupting GPI-anchor biosynthesis in fungi changes cell wall composition and morphology, leading to dispersed growth and altered adhesion.

Mycoelectronics: Bioprinted Living Fungal Bioelectronics for Artificial Sensation

This paper introduces Mycoelectronics, a living fungal-based sensory platform that enables rapid thermal sensing and self-healing through bioprinted mycelium networks integrated with soft electronics.

Dynamic Reprogramming of Fungal Cell Walls Underlies Germination and Immune Exposure in Zygomycetous Fungal Pathogens

This study shows how the cell wall of Rhizopus delemar reprograms during germination, enhancing immune recognition, and identifies key polysaccharide changes involved.

Molecular Architecture of Cryptococcus Cell Walls Reveals Species-Specific Chitosan-Dependent Remodeling

This study examines the structural role of chitosan in Cryptococcus cell walls, revealing species-specific remodeling effects when chitosan is absent.

α-1,3-Glucan-Driven Remodeling of the Conidial Cell Wall in an Aspergillus fumigatus Vaccine Strain Alters Innate Immune Recognition

This study investigates how cell-wall remodeling in an Aspergillus fumigatus vaccine strain affects innate immune recognition through structural and functional analyses.

Precursor-Dependent Routing of Aromatic Amino Acids Determines Lignin Structure in Grasses by Sensitivity-Enhanced Solid-State NMR

This paper uses isotope labeling and solid-state NMR to show how phenylalanine and tyrosine contribute differently to lignin structure in grasses, revealing tyrosine as a compensatory pathway.

Chaotropic Ions Reshape the Cell Wall of the Obligate Halophile Aspergillus atacamensis: Insight from Solid-State NMR

This study uses solid-state NMR to show how NaCl and MgCl2 induce distinct polysaccharide remodeling in the cell wall of Aspergillus atacamensis under hypersaline conditions.

The impact of fungal developmental structures on mechanical properties of mycelial materials.

This study shows that suppressing asexual development in Aspergillus nidulans improves the mechanical strength of mycelial materials, with some mutants also showing increased elasticity due to autolysis.

Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi

This study shows that bacterial metabolites alter C. albicans cell wall composition, affecting antifungal resistance and immune recognition.

Kre6-Dependent β-1,6-glucan Biosynthesis Only Occurs in the Conidium of Aspergillus fumigatus

This study investigates β-1,6-glucan biosynthesis in Aspergillus fumigatus, showing it occurs only in conidia and is regulated by the Kre6 gene.

Emergence of Lignin-Carbohydrate Interactions During Plant Stem Maturation Visualized by Solid-State NMR

The paper uses solid-state NMR to study lignin-carbohydrate interactions in Arabidopsis stems during maturation, revealing the role of specific lignin units and carbohydrates in wall structure.

Rapid High-Resolution Analysis of Polysaccharide-Lignin Interactions via Proton-Detected Solid-State NMR with Application to Eucalyptus and Spruce

This study uses 1H-detected solid-state NMR to rapidly analyze polysaccharide-lignin interactions in eucalyptus and spruce, revealing new structural insights without solubilization.

Solid-State NMR Analysis of Schizosaccharomyces pombe Reveals Role of α-Amylase Family Enzymes in Cell Wall Structure and Function

This paper uses solid-state NMR to study the role of α-amylase family enzymes in S. pombe cell wall structure and function, revealing their non-redundant role with glucan synthase in cell wall synthesis.

Polymorphic α-Glucans as Structural Scaffolds in Cryptococcus Cell Walls for Chitin, Capsule, and Melanin: Insights from 13C and 1H Solid-State NMR

This study uses solid-state NMR to reveal five structural forms of α-glucans in Cryptococcus cell walls, showing their role in scaffolding and interacting with chitin, capsule, and melanin.

Unveiling Cell Wall Structure and Echinocandin Response in Candida auris and Candida albicans via Solid-State NMR

This study uses solid-state NMR to analyze how echinocandin treatment alters cell wall structures in Candida auris and Candida albicans, revealing structural changes linked to drug resistance.

Rho2 regulates granulocyte-triggered stress adaptation and cell wall remodeling in Aspergillus fumigatus

This study shows Rho2 in Aspergillus fumigatus enhances cell wall remodeling and stress resistance against granulocyte attacks, improving survival through upregulation of cell wall biosynthesis.

Proton-Detected Solid-State NMR for Deciphering Structural Polymorphism and Dynamic Heterogeneity of Cellular Carbohydrates in Pathogenic Fungi

Molecular Insights into Cell Wall Architecture and Xylan-Bound Cellulose Fibrils in the Wheat Straw

This study presents a model of xylan-bound cellulose microfibril architecture in wheat straw using ssNMR and X-ray scattering, revealing 18 glucan chains with xylan binding and implications for biomass recalcitrance.

Aspergillus nidulans cell wall integrity kinase, MpkA, impacts cellular phenotypes that alter mycelial-material mechanical properties

This study shows that deleting the MpkA kinase in Aspergillus nidulans alters mycelial material mechanical properties, including increased tensile strength and resistance to fragmentation.

Molecular Architecture of Chitin and Chitosan-Dominated Cell Walls in Zygomycetous Fungal Pathogens by Solid-State NMR

This study uses solid-state NMR to analyze the molecular structure of cell walls in Mucorales fungi, revealing the composition and organization of chitin, chitosan, and associated polysaccharides.

Comparative Analysis of Polysaccharide and Cell Wall Structure in Aspergillus nidulans and Aspergillus fumigatus by Solid-State NMR

This study compares cell wall structure in Aspergillus nidulans and Aspergillus fumigatus using solid-state NMR, revealing similarities and differences in polysaccharide composition and organization.